![]() Serum sodium levels within normal range could therefore also be positively associated with handgrip strength by indicating age-related disruption of microcirculation.įurther, CD34-positive cell concentration is a known factor contributing to endothelial repair 12, while endothelial injury in turn should stimulate CD34-positive cell production 13, 14, 15, 16. In addition, sarcopenia is associated with impairment of capillary function 10 and handgrip strength, a predictor of age-related disability, is an efficient tool for evaluating the decrease in muscle strength and function in the elderly 11. Since hyponatremia is a multifactorial condition related to aging 2, 3, 4, 5, 6, 7, a serum sodium level within the normal range could act as an indicator of age-related change.Ĭapillary function, known as a function of microcirculation is associated with cardiovascular risk factors 8, 9. This study also showed a positive association between serum sodium level and muscle mass evaluated on the basis of mid-arm muscle circumference. These associations could prove to be an efficient tool for clarifying the background mechanism governing the decrease in age-related muscle strength.Įlderly men with low serum sodium levels within the normal range (136–138 mEq/L) showed higher risks of major cardiovascular events and total mortality than those with low serum sodium levels within the upper normal range (139–143 mEq/L) 1. For non-hypertensive elderly subjects, serum sodium concentration within the normal range is positively associated with handgrip strength and inversely associated with CD34-positive cells, thus partly indicating the degree of age-related endothelium injury. Serum sodium concentration was positively associated with handgrip strength in non-hypertensive subjects, but not for hypertensive subjects (β = 0.01 p = 0.878), while it was inversely associated with circulating CD34-positive cell levels in non-hypertensive subjects but not for hypertensive subjects (r = − 0.07 p = 0.454). Subjects were stratified by hypertension status because hypertension should act as a strong confounding factor for the analyses performed in this study. We conducted a cross-sectional study of 246 elderly Japanese men aged 60–69 years. Since endothelial injury stimulates endothelial repair by enhancing CD34-positive cell production, the level of serum sodium may be inversely associated with that of circulating CD34-positive cells, thus indicating the degree of age-related endothelial injury. Serum sodium concentration within the normal range could act as an indicator of age-related changes such as decrease in muscle strength and impairment of capillary function.
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